BIOMARKERS IN PULMONARY ONCOLOGY

A biomarker is a protein or molecular alteration found in a tumor that predicts sensitivity or resistance to one or more specific treatments. In certain circumstances, biomarkers can predict disease prognosis, cancer recurrence, etc. Biomarkers can be detected from tumor tissue or in patients' body fluids, such as blood.

Examples of lung cancer biomarkers:

  • Molecular alterations:
    • Mutations: EGFR, BRAF, ERBB2, MET
    • Oncogenic fusions: ALK, ROS1, RET, NTRK1/2/3
    • Splicing variant: METex14
    • Genetic amplification: EGFR, MET
  • Protein expression alterations: PD-L1